4 edition of Stem Cell Factor Induced Signal Transduction found in the catalog.
by Uppsala Universitet
Written in English
|Series||Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, 1142|
|The Physical Object|
|Number of Pages||59|
Stem Cells. Apr;30(4) doi: /stem Induction of osteogenesis in mesenchymal stem cells by activated monocytes/macrophages depends on oncostatin M signaling. Guihard P(1), Danger Y, Brounais B, David E, Brion R, Delecrin J, Richards CD, Chevalier S, Rédini F, Heymann D, Gascan H, Blanchard F. Increased expression of the putative growth factor receptor p HER2 causes transformation and tumorigenesis of NIH 3T3 cells. in: Proc. Natl. Acad. Sci. USA.
Analyze signal transduction pathways with your own stable cell line! Luciferase vectors with tested cis-responsive elements, or clone your own! cis-elements >>> Expression-ready clones for “ stemness ” genes OCT3/4, SOX2, NANOG, KLF4, LIN28 and c-MYC that have been used to generate induced pluripotent stem (iPS) cells from somatic cells. Induced Pluripotent Stem Cells. The depth of Yamanaka's perception through the discoveries in somatic cell nuclear transfer, 10 cellular fusion, 11 ESC research, 1,12 and understanding of pluripotency related transcription fact14 has led to the landmark discovery in stem cell major breakthrough was the demonstration that ectopic expression .
Together with its ligand, stem cell factor, the receptor tyrosine kinase c-Kit is a key controlling receptor for a number of cell types, including hematopoietic stem cells, mast cells, melanocytes and germ cells. Gain-of-function mutations in c-Kit have been described in a number of human cancers, including testicular germinomas, acute myeloid leukemia and gastrointestinal stromal . Background: Nerve growth factor (NGF) is a potent growth factor that plays a key role in neuronal cell differentiation and may also play a role in hematopoietic differentiation. It has been shown that NGF induced synergistic action for the colony formation of CD34 positive hematopoietic progenitor cells treated with macrophage-colony stimulating factor (M-CSF or CSF-1), or stem cell factor .
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A reference on cellular signaling processes, the third edition of Signal Transduction continues in the tradition of previous editions, in providing a historical overview of how the concept of stimulus-response coupling arose in the early twentieth century and shaped our current understanding of the action of hormones, cytokines, neurotransmitters, growth factors and.
PDF | On Jan 1,Johan Lennartsson and others published Stem Cell Factor Induced Signal Transduction | Find, read and cite all the research you need on ResearchGateAuthor: Johan Lennartsson.
To determine SCF-induced intracellular signal transduction pathways, pTr and pLE cells were incubated with different concentrations of recombinant SCF (0,1, 10, 20 or 50 ng/ml) in serum-reduced medium for 1 h (Fig. 2A).Western blot analyses of pTr cell extracts using antibodies to phosphorylated (p)-AKT protein showed that SCF stimulated, and Cited by: 3.
Stem Cell Factor (SCF) can function as a survival factor, a mitogen or a chemoattractant depending on cell type. Binding of SCF to c-Kit induces dimerization and subsequent autophosphorylation of the receptor.
This thesis describes the intracellular signal transduction elicited by : Johan Lennartsson. the proportion of papers using the term cell that also use the term signal transduction. Major dis - coveries that have boosted signal transduction research are shown underneath the time axis.
The data presented herein support “Generation of an induced pluripotent stem cell line KUMCiA from CD34+ bone marrow cells of a patient with acute. The differentiation of patient-specific induced pluripotent stem cells (iPSCs) into specific neuronal subtypes has been exploited as an approach for m.
Thus mechanical signals have extensive potential to regulate and synergize with classical biochemical signal transduction pathways induced by soluble factors to control stem cell differentiation.
What are the sources and functional consequences of applied mechanical forces on stem cells in vivo. Signal transduction pathways involved in oxidative stress-induced intestinal epithelial cell apoptosis. Pediatr Res. ;–7. CAS. Stem cell factor (also known as SCF, KIT-ligand, KL, or steel factor) is a cytokine that binds to the c-KIT receptor ().SCF can exist both as a transmembrane protein and a soluble cytokine plays an important role in hematopoiesis (formation of blood cells), spermatogenesis, and melanogenesis.
Stem cells are defined by their capacity for self-renewal and ability to differentiate into a variety of somatic cell types. Cellular programs regarding proliferation, potency, and cell fate determination can be mediated by signal transduction events that modulate transcription factor expression and/or activation.
SIGNAL TRANSDUCTION AND HEMATOPOIETIC STEM CELLS “Everyday language is a part of the human organism and is no less complicated than it.”1 The inherent role of communication in the organism manifests distinctively in the hematopoietic stem cell (HSC).
The HSC is a unique cell positioned highest in the hematopoietic hierarchical system. The GSC niche was among the first to be characterized at a single cell level and contributed significantly to the early understanding in the field of how adult stem cell niches function in vivo [8,9].GSC divisions are oriented perpendicular to the niche and are inherently asymmetric, producing two daughter cells that contain unequal cytoplasmic contents and.
signal transduction and targeted therapy (retinoic acid-induced gene 1 enzyme) signal in target cells, M. et al. Stemness-attenuating miRp as a paracrine factor. STI also inhibits the receptors for stem cell factor and PDGF and is therefore potentially useful in lung cancer, where overactivity of the stem cell factor is common ; in dermatofibrosarcoma protuberance, which is characterized by a fusion between the genes for PDGF‐B and collagen IA1 resulting in autocrine stimulation by a PDGF‐like.
Introduction. Basic fibroblast growth factor (bFGF) is a promising cytokine in regenerative therapy for spinal cord injury.
In this study, recombinant canine bFGF (rc-bFGF) was synthesized for clinical use in dogs, and the ability of rc-bFGF to differentiate canine bone marrow mesenchymal stem cells (BMSCs) into functional neurons was investigated.
Controlling apoptosis is also an important focus for studies of stem cell transplantation, where inhibition may increase the survival of grafted cells during replacement therapy. Harnessing the full therapeutic potential of stem cells will require full elucidation of the signal transduction cascades for proliferation, differentiation, and.
For example, adult DP cells were induced to differentiate into adipogenic and osteogenic lineages, as well as in pluripotent stem (iPS) cells. The activity of alkaline phosphatase (ALP) can be used both in mice and human hair follicles as a marker for detecting DP activity [ 40 ].
Since cancer stem cells (CSCs) were first identified in leukemia inthey have been considered promising therapeutic targets for cancer therapy. These cells have self-renewal capacity and. Here the authors build a phosphoregulated relay system in mammalian cells for orthogonal signal transduction.
such as split transcription factor and human-induced pluripotent stem cells. Recent success in reprogramming somatic cells into induced pluripotent stem cells (iPS cells) with a cluster of nuclear transcription factors, such as Oct4, Sox2, Klf4, and c-myc, opens up a new era in regenerative medicine.
However, reportedly poor efficiency and slow kinetics of the reprogramming .Monocyte chemoattractant protein-1 (MCP-1) is a major chemoattractant for monocytes and T lymphocytes. The MonoMac6 cell line was used to examine MCP-1 receptor-mediated signal tr. Breast cancer stem cells (BCSCs) play a critical role in tumor recurrence and metastasis.
Exposure of breast cancer cells to chemotherapy leads to an enrichment of BCSCs. Here, we find that chemotherapy induces the expression of glutathione S-transferase omega 1 (GSTO1), which is dependent on hypoxia-inducible factor 1 (HIF-1) and HIF